Caffè Artigiano opened in downtown Vancouver in January 2000 as an Italian-style coffee house and bistro. In April 2002, a second downtown location opened on Hornby Street, off Robson. Since then, the company has opened additional locations in Vancouver, West Vancouver, Burnaby, Victoria and Calgary. As of May 2014, it had a total of 15 retail locations in addition to its head office.
Major local competitors include Starbuck's, Tim Horton's, Bean Around the World, Blenz and Waves. A new entry into the local market is Faubourg in Kerrisdale.